Longitudinal cluster randomised trials

Much of my recent work has focussed on the development of methodology for longitudinal cluster randomised trials, including the stepped wedge design and multi-cross-over cluster trial.

Causal Inference

Many of my recent projects have been in the development of theory for causal inference.

Healthcare provider comparison

I have been involved in several projects comparing the performance of healthcare providers.

Preventing sexual harassment within the stats community

Preventing sexual and other forms of harassment within the statistical community is something I have been working on over the last year or so.

Methods Publications

  1. M McGuinness, J Kasza, A Karahalios, R Guymer, RP Finger, JA Simpson. A comparison of methods to estimate the survivor average causal effect in the presence of missing data: a simulation study. BMC Medical Research Methodology, (2019) 19:223.

  2. K Grantham, J Kasza, S Heritier, K Hemming, E Litton, A Forbes. How many times should a cluster randomized crossover trial cross over? Statistics in Medicine. 2019:38(25);5021-5033.

  3. J Kasza, M Taljaard, A Forbes. Information content of stepped-wedge designs when treatment effect heterogeneity and/or implementation periods are present. Statistics in Medicine. Accepted 2019.

  4. K Grantham, A Forbes, S Heritier, J Kasza. Time Parameterizations in Cluster Randomized Trial Planning. The American Statistician. Accepted 2019.

  5. K Grantham, J Kasza, S Heritier, K Hemming, A Forbes. Accounting for a decaying correlation structure in cluster randomized trials with continuous recruitment. Statistics in Medicine. 2019:38(11);1918-1934.

  6. J Kasza, A Forbes. Inference for the treatment effect in multiple-period cluster randomised trials when random effect correlation structure is misspecified. Statistical Methods in Medical Research. (2019) 28(10-11):3112-3122.

  7. J Kasza, A Forbes. Information content of cluster-period cells in stepped wedge trials. Biometrics. (2019) 75(1):144-152.

  8. J Kasza, KR Polkinghorne, R Wolfe, SP McDonald, MR Marshall. Comparing dialysis centre mortality outcomes across Australia and New Zealand: identifying unusually performing centres 2008–2013. BMC Health Services Research. (2018) 18:1007.

  9. R Herbert, J Kasza, K Bo. Analysis of randomised trials with long-term follow up. BMC Medical Research Methodology. 2018; 18(48)

  10. J Kasza, K Hemming, R Hooper, JNS Matthews, A Forbes. Impact of non-uniform correlation on sample size and power in multiple period cluster randomised trials. Statistical Methods in Medical Research. (2019) 28(3):703-716.

  11. J Kasza, R Wolfe, T Schuster. Assessing the impact of unmeasured confounding for binary outcomes using confounding functions. International Journal of Epidemiology. (2017) 46(4):1303–1311.

    • Winner of the 2018 Monash University John McNeil Early Career Researcher Publication Prize for Public Health Research

  12. C Oates*, J Kasza*, JA Simpson, A Forbes. (*Joint first authors) Repair of partly misspecified causal diagrams. Epidemiology. 28(4):548–552.

  13. M McGuinness, A Karahalios, J Kasza, R Guymer, RP Finger, JA Simpson. Survival bias when assessing risk factors for age-related macular degeneration: a tutorial with application to the exposure of smoking. Ophthalmic Epidemiology, (2017) 24(4):229-238.

  14. C Oates, J Kasza, S Mukherjee. Discussion of “Causal inference by using invariant prediction: identification and confidence intervals”. Journal of the Royal Statistical Society, Series B, (2016) 78(5):1003.

  15. J Kasza, KR Polkinghorne, SP McDonald, MR Marshall, R Wolfe. Clustering and residual confounding in the application of marginal structural models to registry data: dialysis, vascular access, and mortality. American Journal of Epidemiology, (2015) 182(6):535-543.

    • Winner of the 2016 Monash University John McNeil Early Career Researcher Publication Prize for Public Health Research
    • Winner of the 2016 AMREP Public Health Research Mid-Career Researcher Best Paper Award

  16. JA Flegg, J Kasza, I Darby and CD Weller. Healing of venous ulcers using compression therapy: predictions of a mathematical model. Journal of Theoretical Biology. (2015) 379:1-9.

  17. J Kasza. Stata tip 125: Binned residual plots for assessing the fit of regression models for binary outcomes. The Stata Journal. (2015) 15(2):599-604.

  18. J Kasza, JL Moran and PJ Solomon. Assessing changes over time in health-care provider performance: addressing regression to the mean over multiple time points. Biometrical Journal. (2015) 57(2):271-285.

  19. J Kasza and PJ Solomon. Comparing score-based methods for estimating Bayesian networks using the Kullback-Leibler divergence. Communications in Statistics: Theory and Methods. (2015) 44(1):135-152.

  20. J Kasza, D Wraith, K Lamb and R Wolfe. Survival analysis of time-to-event data in respiratory health studies. Respirology. (2014) 19(4):483-492.

  21. J Kasza and R Wolfe. Interpretation of commonly used statistical regression models. Respirology. (2014) 19(1):14-21.

  22. PJ Solomon, J Kasza and JL Moran. Identifying unusual performance in Australian and New Zealand intensive care units from 2000 to 2010. BMC Medical Research Methodology. (2014) 14:53.

  23. J Kasza, JL Moran and PJ Solomon. Evaluating the performance of Australian and New Zealand intensive care units in 2009 and 2010. Statistics in Medicine. (2013) 32(21):3720-36.

  24. J Kasza, G Glonek, and PJ Solomon. Estimating Bayesian networks for high-dimensional data with complex mean structure and random effects. Australian and New Zealand Journal of Statistics. (2012) 54(2):169-87.

Collaborative Publications


  1. KL Paterson, J Kasza, DJ Hunter, RS Hinman, HB Menz, G Peat, KL Bennell. Longitudinal association between foot and ankle symptoms and worsening of symptomatic radiographic knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis and Cartilage, (2017) 25(9):1407-1413.
  2. DR McIlroy, D Murphy, J Kasza, D Bhatia, L Wutzlhofer, S Marasco. Effects of restricting perioperative use of intravenous chloride on kidney injury in patients undergoing cardiac surgery: the LICRA pragmatic controlled trial. Intensive Care Medicine, (2017) 43(6):795–806.
  3. A van Ginckel, K Bennell, P Campbell, J Kasza, T Wrigley, D Hunter, R Hinman. Associations between changes in knee pain location and clinical symptoms in people with medial knee osteoarthritis using footwear for self-management: an exploratory study. Osteoarthritis and Cartilage, (2017) 25(8):1257-1264.
  4. M Matthews, M Skovdal Rathleff, A Claus, T McPoil, R Nee, K Crossley, J Kasza, S Paul, R Mellor, and B Vicenzino. The Foot Orthoses versus Hip eXercises (FOHX) trial for patellofemoral pain: a protocol for a randomized clinical trial to determine if foot mobility is associated with better outcomes from foot orthoses. Journal of Foot and Ankle Research, (2017) 10:5.
  5. KL Bennell, R Nelligan, F Dobson, C Rini, F Keefe, J Kasza, S French, C Bryant, A Dalwood, J. H Abbott, RS Hinman. Effectiveness of an internet-delivered exercise and pain coping skills training intervention for people with chronic knee pain (IMPACT–knee pain): A randomised controlled trial. Annals of Internal Medicine, (2017) 166(7):453-462.
  6. A Van Ginckel, RS Hinman, TV Wrigley, DJ Hunter, CJ Marshall, L Melo, SRF Meneses, M Simic, J Kasza, J Duryea, JA Wallis, KL Bennell; Impact of Cane Use on Bone Marrow Lesion Volume in People With Medial Knee Osteoarthritis (CUBA Trial), Physical Therapy, (2017) 97(5):537–549.
  7. RS Hinman, BJ Lawford, PK Campbell, AM Briggs, J Gale, C Bills, SD French, J Kasza, A Forbes, A Harris, SJ Bunker, CM Delany, KL Bennell. Telephone-Delivered Exercise Advice and Behavior Change Support by Physical Therapists for People with Knee Osteoarthritis: Protocol for the Telecare Randomized Controlled Trial. Physical Therapy, (2017) 97(5):524–536.
  8. E Paul, M Bailey, J Kasza, D Pilcher. Assessing contemporary intensive care unit outcome: Development and validation of the Australian and New Zealand Risk of Death Admission model. Anaesthesia and Intensive care, (2017) 45(3):326-343.
  9. K Leslie, M Allen, E Hessian, P Peyton, J Kasza, $\ldots$, CX O’Kane. Safety of sedation for gastrointestinal endoscopy in a group of university-affiliated hospitals: a prospective cohort study. British Journal of Anaesthesia, (2017) 118(1):90-99.
  10. T Corcoran, J Kasza, TG Short, E O’Loughlin, MTV Chan, K Leslie, A Forbes, M Paech, P Myles. Intraoperative dexamethasone administration does not increase the risk of post-operative wound infection: a propensity score matched post-hoc analysis of the ENIGMA-II trial (EnDEX). British Journal of Anaesthesia, (2017) 118(2):190–199.
  11. KL Paterson, J Kasza, DJ Hunter, RS Hinman, HB Menz, G Peat, KL Bennell. The relationship between foot and ankle symptoms and risk of developing knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis and Cartilage, Accepted 1 December 2016.
  12. KL Paterson, KL Bennell, TV Wrigley, BR Metcalf, J Kasza, RS Hinman. Effects of footwear on the knee adduction moment in medial knee osteoarthritis: flat flexible versus stable supportive shoes. Osteoarthritis and Cartilage, (2017) 25(2):234-241.
  13. M Hall, KL Bennell, TV Wrigley, BR Metcalf, PK Campbell, J Kasza, KL Paterson, DJ Hunter, RS Hinman. The knee adduction moment and knee osteoarthritis symptoms: relationships according to radiographic disease severity. Osteoarthritis and Cartilage, (2017) 25(1):34-41.
  14. M Hall, KL Bennell, TV Wrigley, J Kasza, FL Dobson, YH Pua, BR Metcalf. Cross-sectional association between muscle strength and self-reported physical function in 195 hip osteoarthritis patients. Seminars in Arthritis and Rheumatism, (2017) 46(4):387-394.
  15. KL Bennell, P Campbell, T Egerton, B Metcalf, J Kasza, A Forbes, C Bills, J Gale, A Harris, G Kolt, S Bunker, D Hunter, C Brand, R Hinman. Telephone coaching to enhance a home-based physical activity program for knee osteoarthritis: a randomized controlled trial. Arthritis Care & Research, (2017) 69(1):84–94.


  1. J Kasza, R Wolfe, SP McDonald, MR Marshall, KR Polkinghorne. Dialysis modality, vascular access and mortality in end-stage renal disease: a binational registry-based cohort study. Nephrology, (2016) 124(10):878-886.
  2. M Chan, P Peyton, PS Myles, K Leslie, N Buckley, J Kasza, MJ Paech, WS Beattie, DI Sessler, A Forbes, S Wallace, Y Chen, Y Tian, WKK Wu. Chronic postsurgical pain in the evaluation of nitrous oxide in the gas mixture for anaesthesia (ENIGMA)-II trial. British Journal of Anaesthesia, (2016) 117(6):801-811.
  3. RS Hinman, TV Wrigley, B Metcalf, P Campbell, K Paterson, D Hunter, J Kasza, A Forbes, KL Bennell. Unloading shoes to self-manage knee osteoarthritis: findings of the SHARK randomized controlled trial. Annals of Internal Medicine, (2016) 165(6):381-389.
  4. P Myles, M Chan, J Kasza, M Paech, K Leslie, P Peyton, D Sessler, G Haller, WS Beattie, C Osborne, JR Sneyd, A Forbes, and the ANZCA Clinical Trials Network. Severe nausea and vomiting in the ENIGMA-II trial. Anesthesiology. (2016) 21(5):1032-1040.
  5. KL Bennell, Y Ahamed, G Jull, C Bryant, MA Hunt, A Forbes, J Kasza, M Akram, B Metcalf, A Harris, T Egerton, JA Kenardy, MK Nicholas, and FJ Keefe. Physical therapist-delivered pain coping skills training and exercise for knee osteoarthritis: randomized controlled trial. Arthritis Care & Research, (2016) 68(5):590-602.
  6. P Myles, J Kasza. Letter to the Editor: Physician performance rankings based on outcomes, confirmed by the same outcomes: a tautology. Anesthesia & Analgesia, (2016) 122(5):1718-1719.
  7. E Paul, M Bailey, J Kasza, D Pilcher. Application of the Australian and New Zealand Risk of Death model for benchmarking intensive care outcomes and detection of outliers. Critical Care and Resuscitation, (2016) 18(1):25-36.
  8. K Leslie, D McIlroy, J Kasza, A Forbes, A Kurz, J Khan, C Meyhoff, R Allard, G Landoni, X Jara, G Lurati Buse, K Candiotti, H-S Lee, R Gupta, T VanHelder, W Purayil, S De Hert, T Treschan and PJ Devereaux. Neuraxial block and postoperative epidural analgesia: effects on outcomes in the POISE-2 trial. British Journal of Anaesthesia. (2016) 116(1):100-112.


  1. K Leslie, P Myles, J Kasza, A Forbes, P Peyton, M Chan, M Paech, D Sessler, WS Beattie, PJ Devereaux and S Wallace. Nitrous oxide and serious long-term morbidity and mortality in the ENIGMA-II trial. Anesthesiology. (2015) 123(6):1267-1280.
  2. KL Bennell, C Rini, F Keefe, S French, R Nelligan, J Kasza, A Forbes, F Dobson, J Haxby Abbott, A Dalwood, B Vicenzino, A Harris and RS Hinman. Effects of adding an internet-based pain coping skills protocol to a standardized education and exercise program for people with persistent hip pain (HOPE Trial): Randomized controlled trial protocol. Physical Therapy. (2015) 95:1408-1422.

Selected presentations

  1. International Society for Clinical Biostatistics 2020.

  2. International Biometrics Society Journal Club invited speaker.

  3. Pragmatic cluster randomised trial designs workshop, Melbourne November 2019.

  4. Society for Clinical Trials, Portland USA, May 2018.

  5. Society for Clinical Trials & 4th International Clinical Trials Methodology Conference, Liverpool UK, May 2017.

  6. Australian Statistics Conference, Canberra, December 2016.

  7. 37th Annual Conference of the International Society for Clinical Biostatistics, Birmingham UK, August 2016.

    • Causal diagrams, expert opinion and structure learning: vetting the expert.

  8. Biometrics by the Harbour, Conference of the Australasian Region of the International Biometric Society, Hobart, November 2015.

  9. Australian Clinical Trials Alliance International Clinical Trials Symposium, Sydney, October 2015.

  10. 36th Annual Conference of the International Society for Clinical Biostatistics, Utrecht, August 2015.

  11. 35th Annual Conference of the International Society for Clinical Biostatistics, Vienna, August 2014.


  • Click here for my CV.